As a high proportion of distributed renewable energy is connected to the power grid, prosumers gradually become an important role in demand-side coordination and optimization. Meanwhile, the problem of response delay of massive resources becomes more obvious in demand-side real-time regulation. Therefore, combined with 5G technology enabling, a real-time regulation and optimization strategy is proposed for prosumers considering 5G communication and shared energy storage. Firstly, the real-time regulation architecture of prosumers based on 5G cloud-edge collaboration is designed. Secondly, the regulation service delay model based on 5G is constructed from two aspects of transmission delay and calculation delay. Then, a real-time operation optimization model considering delay compensation and energy-capacity sharing storage service is established, where the upper objective function is to maximize the revenue of the edge layer aggregator, and the lower objective function is to minimize the total operating cost of all prosumers in the end layer；Finally, simulation results show that the proposed strategy can effectively reduce load deviation caused by delay, improve the new energy consumption capacity, and improve the operational revenue of aggregators, reduce energy consumption costs of prosumers, achieving rapid and precise regulation of demand side resources.