In order to promote the application of load demand response technology in the distribution network and improve the efficiency of the distribution network transaction operation, a multiagent transaction strategy of the distribution network considering the load demand response potential is proposed. Firstly, a calculation method for load participation in demand response potential is established based on Minkowsky sum, the distributed active loads are aggregated into generalized loads for unified scheduling. Then,according to the profit model of each transaction entity in the distribution network, the mathematical model of each entity is established, and the two-layer multi-objective optimization model is constructed with the largest overall income of the distribution network and the largest income of each entity as the objective function. Finally, MultiGPO algorithm is used to solve the optimization problem.The results show that the constructed distribution network model can reasonably distribute the benefits of each entity under the premise of the maximum benefit of the distribution network, thereby improve the economy of the distribution network as a whole and a single individual. At the same time, the MultiGPO algorithm is compared with traditional algorithms can obtain better optimization results.