Multi- region integrated energy system can improve energy efficiency, promote the absorption of renewable energy, and reduce energy waste and emission effectively. Multi-region integrated energy system involves several kinds of energy systems and is difficult to operate of cooperative optimization. So the article establishes the framework of integrated energy system and multi-region integrated energy management system. The functions of the component are analysed in the article. On this basis, the architecture of multi- region integrated energy management system based on multi-agent technology is established. The framework of energy management system includes energy management center generalagent of multi- region integrated energy system, learning center agent, solution center agent and sub- agent of energy management system. The functions of each agent and the working flow of the system are introduced in detail. At last, the JADE platform is built to realize the run of the system.