Flexible optimization of reconfiguration operation is one of the main features in smart distribution systems. As the multi-carrier energy coupling growing, the integrated energy transformation components, such as energy hub, gains increasing concerns. The research is still needed on how to optimize the topology reconfiguration considering integrated demand response such that more flexibility and economics could be achieved. A topology reconfiguration optimization and solution methodology model is presented in distribution systems considering integrated energy demand response. The traditional demand response in power users are extended to multi-energy users. The distribution topology reconfiguration is optimized coordinately with the integrated demand response to realize the global optimum of distribution systems and all users. The case studies verify the effectiveness of the proposed model and algorithm.