In order to meet the increasing energy demand of ports and decrease the environment pollution in port areas, the mode of port energy supply has gradually transformed from the traditional mode of oil and coal-fired power supply to integrated energy supply including cooling, heating, electric power and natural gas.The development of the shore-to-ship power supply system and infrastructure electrification has furtherly increased the demand for electricity. An optimal operation method of port integrated energy system（PIES）considering integrated demand response（IDR）is proposed. A multi-energy coupling conversion model of PIES based on energy hub is built by analyzing the coupling connection of energy conversion among equipment in PIES, and an IDR model of port is established based on the classification of port loads. On this basis,comprehensively considering the impact of energy prices, environment pollution, energy loss and other factors on the operation of PIES, an optimal operation model of PIES considering IDR is constructed. The proposed method is applied to a PIES, and the simulation results show that this method can effectively reduce the total operation cost of PIES and effectively reduce the peak demand of electric power load.