Under the background of fast development of electricity demand-side response technique, the electric-power system of industrial park introduces different energy types such as gas, hydrogen to achieve comprehensive energy supply. As a result, the participation ability and intensity of demand-side response are significantly improved by the introduction of integrated energy system, and the utilization of renewable energy power is also promoted. In this study, the structure design and optimal dispatching of integrated energy system in industrial park under the background of electricity demand-side response are analyzed and researched, and the topology of integrated energy system including the thermal, electricity and hydrogen energy forms is developed. In addition, the optimal dispatching model is also established by introducing the complex constraints, in order to achieve economical operation of integrated energy system under the background of electricity demand-side response, in which the multi-energy loads are included. Experimental results show that the demand-side response participation of multi-energy loads can be effectively promoted by the introduction of integrated energy system, the operation cost can be reduced while the electric power demand during peak-period is decreased, and the utilization of renewable energy power is also significantly improved.