In order to plan distribution system under the background of electric energy substitution, firstly considering the technical situation of various potential users such as electric oil substitution, electric coal substitution, electric gas substitution, a game model of distribution network expansion planning with multi-agent self-drive optimal decision-making is constructed, and a closed-loop decision-making chain of“expansion planning-market transaction-substitution decision”is formed. Then, the distribution system operator planning model considering operation control and the economic energy consumption model of users with multiple electric energy substitution potential are introduced respectively. A two-layer model of distribution network expansion planning including comprehensive electric energy substitution is formed, and the solution method of the model is proposed. Finally, an improved IEEE 33-node distribution system is selected for analysis. This method can reduce the total cost by about 30%, taking into account the flexibility to cope with load growth and multi-agent interaction. The results show that this method can effectively improve the operating margin to cope with the load growth and avoid the reduction of power reliability caused by the secondary programming. It is a new method of distribution network planning for the two-carbon target.