As the basis of energy Internet, integrated energy system is an important technology to improve energy utilization and renewable energy consumption. By guiding users to change their habits and ways of energy consumption, demand response has been paid more and more attention to optimize the load distribution and improve the economy of system operation. Based on the refined modeling of the comprehensive demand response on the user demand side, a refined model considering the reducible load, translatable load, transferable load and replaceable load is established with the total operation cost of the integrated energy system as the lowest. The day-ahead optimal scheduling of the integrated energy system considering the comprehensive demand response is proposed. The case study shows that the comprehensive demand response can optimize the load curve of the park and improve the energy utilization and the economy of the system operation.