Data center is one of the important loads in the multi -station integration. A comprehensive comparison between DC and AC power supply architectures is focused to consider the effect of entire power supply modes on data center. Firstly, the typical DC and AC power supply architectures are analyzed. Then, a comprehensive assessment method considering economic, reliability, and controllability is developed. Finally, the comparison of the typical architectures based on the assessment method is applied.The results show that the DC has significant advantages over AC on economic, reliability and controllability. With the development of the DC technologies, the assessment method is supposed to be applied on more scenarios or developed to make more comprehensive and specific comparison.