In view of the good energy-saving and demand response potential of commercial buildings, an intelligent energy-using control system for commercial buildings based on cyber physical system（CPS）architecture is proposed. Based on the three-tier architecture of typical CPS system, unit level realizes dynamic information perception, standardized information modeling and control of energy-using systems such as air conditioning, lighting and electric heating through intelligent energy-using terminals. System level implements multi - information fusion and edge calculation through intelligent energy-using gateway to realize building energy efficiency analysis, energy efficiency diagnosis and coordinated control of multi-equipment. Platform level implements aggregation and synergetic optimization of energy response potential of multi-commercial buildings through intelligence. Take a commercial building in Shenzhen as an example, an intelligent control and management system based on CPS architecture is deployed and applied.The results show that responsiveness of energy regulation and control is significantly improved, and energy consumption is signifi-cantly reduced.