With the exhaustion of traditional fossil energy and the increase of energy demand, low efficiency and unsustain able production, traditional energy has shown many shortcomings.The introduction of multienergy supply system can improve the comprehensive utilization efficiency, promote the development of renewable energy, enhance the reliability of power supply, and meet the needs of special places. In this paper, the comprehensive evaluation index system and method of regional multienergy supply system are studied. Firstly, the typical regional multienergy supply system structure is constructed. Secondly, the comprehensive evaluation index system of regional multienergy supply system is constructed from the aspects of energy efficiency, economy and environ mental protection. Then, DEMATELANPAnti Entropy combinatorial method and the improved grey correlation method are respectively used to determine the weights of each evaluation factor in criterion layer and indictor layer, and the polynomial interpolation method is used to construct the index scoring function of regional multienergy supply system. Finally, a comprehensive evaluation of the regional multienergy supply system in a residential area of Jiangsu province is carried out, and the research results verify the feasibility and effectiveness of the proposed evaluation index system and evaluation methodk.