According to the characteristics of regional power grid, the electricity transaction among electricity distribution company, power grid company and electricity customer is studied. Considering the differences between supply and demand during the transaction process, a non cooperative game selling strategy model based on transmission cost optimization is established. Taking regional power grid as an example, the Nash equilibrium power sales strategy of various stakeholders is analyzed under the non?coopera?tivegame model. Results show that the model not only provides bidding reference for the sales company and balances the benefits between renewable energy and traditional thermal power, but also reduces the imbalance probability of regional power supply and demand and ensures the safe operation of the electricity market.